GPCR 신호전달 및 그 외 세포 내 주요 신호전달 단백질의 분자적, 구조적 작용기전 규명
학력
이학박사: Molecular and Cellular Pharmacology, University of Wisconsin-Madison
약학석사: 서울대학교 약학대학 약학과
약학사: 서울대학교 약학대학 제약학과
약력/경력
2008-2011: 박사후연구원, Stanford University
2012-2016: 조교수, 성균관대학교 약학대학
2017-present: 부교수, 성균관대학교 약학대학
학술지 논문
(2024)
Molecular mechanism of muscarinic acetylcholine receptor M3 interaction with Gq.
COMMUNICATIONS BIOLOGY.
7,
(2024)
Molecular insights into atypical modes of β-arrestin interaction with seven transmembrane receptors.
SCIENCE.
383,
6678
(2023)
GPCR targeting of E3 ubiquitin ligase MDM2 by inactive β-arrestin.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA.
120,
28
(2023)
Gαs slow conformational transition upon GTP binding and a novel Gαs regulator.
ISCIENCE.
26,
5
(2022)
Effect of ?-helical domain of Gi/o ? subunit on GDP/GTP turnover.
BIOCHEMICAL JOURNAL.
479,
17
(2021)
Scaffolding mechanism of arrestin-2 in the cRaf/MEK1/ ERK signaling cascade.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA.
118,
37
(2021)
The conformational transition during G protein-coupled receptor (GPCR) and G protein interaction.
CURRENT OPINION IN STRUCTURAL BIOLOGY.
69,
Special SI
(2021)
Conformational switch that induces GDP release from Gi.
JOURNAL OF STRUCTURAL BIOLOGY.
213,
1
(2021)
Structure of a GRK5-Calmodulin Complex Reveals Molecular Mechanism of GRK Activation and Substrate Targeting.
MOLECULAR CELL.
81,
2
(2020)
Many faces of the GPCR-arrestin interaction.
ARCHIVES OF PHARMACAL RESEARCH.
43,
9
(2020)
Crystal Structure of beta-Arrestin 2 in Complex with CXCR7 Phosphopeptide.
STRUCTURE.
28,
9
(2020)
Structural mechanism underlying primary and secondary coupling between GPCRs and the Gi/o family.
NATURE COMMUNICATIONS.
11,
1
(2020)
Conformational Dynamics and Functional Implications of Phosphorylated beta-Arrestins.
STRUCTURE.
28,
3
(2019)
Assembly of a GPCR-G Protein Complex.
CELL.
177,
5
(2019)
Structural Mechanism of the Arrestin-3/JNK3 Interaction.
STRUCTURE.
27,
7
(2018)
Biophysical and functional characterization of Norrin signaling through Frizzled4.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA.
115,
35
(2018)
Orthosteric and allosteric action of the C5a receptor antagonists.
NATURE STRUCTURAL & MOLECULAR BIOLOGY.
25,
6
(2017)
Structural and Functional Analysis of a beta(2)-Adrenergic Receptor Complex with GRK5.
CELL.
169,
3
수상/공훈
2006 : Predoctoral Fellowship, American Heart Association
2007 : Vilas Travel Grant Award
2010 : Senior Scientist Fellowship, American Lung Association
2012 : 차세대선도과학자, 한국과학기술한림원
2017 : 신진학술상, 한국응용약물학회
2019 : WBF-코스맥스 여성과학약진상, 여성생명과학기술포럼/코스맥스(주)
2019 : 차세대선도약학자상, 대한약학회
2019 : 과학기술정보통신부 ‘2019 올해의 기초연구자’ 장관상 표창
2021 : 제2회 에쓰-오일 차세대과학자상
학술회의논문
(2024)
Dynamic conformational change during GPCR-G protein coupling.
wcp2023.
영국
